Heavy metal pollution of the environment is a persistent concern to both biotic and abiotic elements. Numerous harmful effects, including neurotoxicity and apoptotic cell death, have been connected to heavy metals like mercury, arsenic, cadmium, and lead. Despite the fact that these metals are necessary for regular biological processes, their biomagnification within cells has negative consequences. The generation of free radicals in heavy metal-induced neurotoxicity upsets the equilibrium between the oxidative and antioxidative defense mechanisms, leading to oxidative stress. Necrosis, DNA damage, and neurological diseases are linked to this stress. This brief study summarizes what is now known about the ability of natural compounds derived from various herbs and plants to protect against neurotoxicity caused by heavy metals. Knowing these defense mechanisms helps develop mitigation methods for the harmful impacts of heavy metal exposure.